The pulling through study: a follow-up (Genetic polymorphisms and risk of secondary lymphoedema after breast cancer: a nested case-control study)

Overview

In 2002-2003, 287 women from south-east Queensland newly diagnosed with breast cancer, participated in the Pulling Through Study. This study was designed to advance our understanding of the physical and psychosocial recovery experienced by Australian breast cancer survivors.

This follow-up study carried out in 2008-2009 revisited 195 women from the original study and aims to quantify the magnitude of secondary lymphoedema and related functional impairment in women 6 years after their diagnosis of breast cancer. This study will also determine whether it is possible to identify a subset of women who are most likely to develop lymphoedema due to inherited genetic susceptibility. This might lead to introducing genetic testing and counselling protocols to target intensive monitoring for earlier diagnosis of lymphoedema when management may be more effective in reducing the severity of lymphoedema and associated disability.

Clearer understanding of the determinants of secondary lymphoedema, both biological and otherwise, may reveal opportunities for prevention and more effective treatment.  At a minimum, we should be able to improve information given to clinicians and women with breast cancer, to help them better anticipate and manage their physical recovery from the disease.

Publications

Schmitz KH, Speck RM, Rye SA, DiSipio T, Hayes SC (2012) Prevalence of breast cancer treatment sequelae over six years of follow-up: The Pulling Through Study. Cancer. 118(8): 2217-2225.

Newman B, Lose F, Kedda M, Francois M, Ferguson K, Janda M, Yates P, Spurdle A, Hayes S. (2012) Possible genetic predisposition to lymphedema after breast cancer. Lymphatic Research and Biology. (in press).

Hayes S, DiSipio T, Rye S, Lopez JA, Saunders C, Pyke C, Bashford J, Battistutta D, Newman B. (2011) Prevalence and prognostic significance of secondary lymphedema following breast cancer. Lymphatic Research and Biology. 9(3): 135-141.

Di Sipio T, Hayes S, Battistutta D, Newman B, Janda M (2011). Patterns, correlates, and prognostic significance of quality of life following breast cancer. Psycho-Oncology. Oct;20(10):1084-1091.

Research Grants

Title of project Chief investigators Funding body Period of funding
Genetic polymorphisms and risk of secondary lymphoedema after breast cancer: a nested case-control study

 

Hayes S, Spurdle M, Janda M, Yates P, Ward L, Newman B.

 

Cancer Australia/National Breast Cancer Foundation

 

2008-2009